Sex Bias in Pre-Clinical Biomechanical Studies of Orthopaedic Implants Summer 2015

sex-biasParticipants: Richard Hughes and Chien-Yu Lin

Project Contact: Richard E. Hughes, Ph.D., rehughes@umich.edu

Project Synopsis: There is evidence that failure to test drugs in female animals and cells in pre-clinical studies have contributed to drug side effects in women. It is unclear to what extent the same is true for medical devices used in orthopaedic surgery. The objective of this project is to characterize the sex of test subjects in pre-clinical studies of hip and knee replacement implants. For computational models such as finite element analyses, which are commonly used to analyze implants, the purpose is to characterize the source of model input data with respect to sex. The intended outcome of this project is to inform industry and public policy makers.

Papers, Posters, & Presentations:

Papers

Posters

  • Analysis of appropriately selected study populations in American Society of Biomechanics (ASB) abstracts over time, 7th World Congress of Biomechanics, July 2014

Acknowledgements: Sarah Bach, a former CHEPS student, who conducted the first study for this project.